Potentiation by aminopeptidase P of blood pressure response to bradykinin
| Autor: | Shin-Ichi Kitamura, O. A. Carretero, W. H. Simmons, Alfonso G. Scicli, Luis A. Carbini |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Hemodynamics Bradykinin Blood Pressure Aminopeptidases chemistry.chemical_compound Maximum blood pressure Lisinopril Internal medicine medicine Animals Rats Wistar Pharmacology biology Dose-Response Relationship Drug Chemistry Area under the curve Rats Endocrinology Blood pressure Enzyme inhibitor ACE inhibitor biology.protein medicine.drug circulatory and respiratory physiology Research Article |
| Zdroj: | British journal of pharmacology. 114(1) |
| ISSN: | 0007-1188 |
| Popis: | We examined whether a specific aminopeptidase P (APP) inhibitor, apstatin, increases vasodepressor responses to bradykinin in anaesthetized rats, and whether it would augment blood pressure responses further after treatment with the angiotensin-converting enzyme inhibitor (ACEi), lisinopril. Apstatin doubled the maximum blood pressure response to bradykinin. The area under the curve (AUC), which incorporates both peak blood pressure changes and duration of response, was doubled in apstatin-treated rats vs controls and in the apstatin+lisinopril group vs lisinopril alone. These data demonstrate that APP is an important kinase in vivo. |
| Databáze: | OpenAIRE |
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