The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets
| Autor: | Mahadevappa Hemshekhar, Kesturu S. Girish, Somanathapura K. NaveenKumar, Bidare N SharathBabu, Govindasamy Mugesh, Kempaiah Kemparaju |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Platelets
0301 basic medicine Programmed cell death Phenylenediamines medicine.disease_cause Biochemistry Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Platelet Heme chemistry.chemical_classification Cyclohexylamines Reactive oxygen species Cell Death Hydroxyl Radical General Medicine Platelet Activation medicine.disease Hemolysis Cell biology 030104 developmental biology chemistry 030220 oncology & carcinogenesis Hemin Molecular Medicine Lipid Peroxidation Hemoglobin Heme Oxygenase-1 Oxidative stress |
| Zdroj: | ACS Chemical Biology. 13:1996-2002 |
| ISSN: | 1554-8937 1554-8929 |
| DOI: | 10.1021/acschembio.8b00458 |
| Popis: | Hemolysis, a process by which the destruction of red blood cells leads to the release of hemoglobin, is a critical event observed during hemolytic disorders. Under oxidative stress conditions, hemoglobin can release its heme prosthetic group, which is highly cytotoxic and can catalyze the generation of reactive oxygen species (ROS), leading to several undesired redox reactions in the cells. Herein, we demonstrate for the first time that heme can mediate the activation and death of human platelets through ferroptosis, which is an iron-dependent form of nonapoptotic cell death. This study also suggests that the heme-mediated lipid peroxidation and ferroptosis in platelets may play an important role in hemolytic disorders. |
| Databáze: | OpenAIRE |
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