| Autor: |
Chang-Yuil Kang, Yeonseok Chung, Byung-Seok Kim, Hyun-Ja Ko, Hyungseok Seo, Eun-Ah Bae, Tae-Seung Kang, Kwang-Soo Shin, Insu Jeon, Choong-Hyun Koh, Il-Kyu Kim |
| Rok vydání: |
2023 |
| DOI: |
10.1158/2326-6066.c.6550072 |
| Popis: |
GM-CSF as an adjuvant has been shown to promote antitumor immunity in mice and humans; however, the underlying mechanism of GM-CSF–induced antitumor immunity remains incompletely understood. In this study, we demonstrate that GM-CSF potentiates the efficacy of cancer vaccines through IL9-producing Th (Th9) cells. GM-CSF selectively enhanced Th9 cell differentiation by regulating the COX2–PGE2 pathway while inhibiting the differentiation of induced regulatory T (iTreg) cells in vitro and in vivo. GM-CSF–activated monocyte-derived dendritic cells converted tumor-specific naïve Th cells into Th9 cells, and delayed tumor growth by inducing antitumor CTLs in an IL9-dependent manner. Our findings reveal a mechanism for the adjuvanticity of GM-CSF and provide a rationale for the use of GM-CSF in cancer vaccines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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