Microscopic colitis in patients with ulcerative colitis or Crohn's disease: a retrospective observational study and review of the literature
| Autor: | Anna Wickbom, Anders Eriksson, Kjell-Arne Ung, Lina Vigren, Nils Nyhlin, Andreas Münch, Åke Öst, Curt Tysk, Johan Bohr, A. Lapidus |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Colitis Lymphocytic Male Lymphocytic colitis medicine.medical_specialty Adolescent medicine.medical_treatment Colitis Collagenous Inflammatory bowel disease Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Microscopic colitis Crohn Disease Internal medicine medicine Humans Child Colectomy Aged Retrospective Studies Sweden Crohn's disease Collagenous colitis business.industry Retrospective cohort study Middle Aged medicine.disease Ulcerative colitis digestive system diseases 030220 oncology & carcinogenesis Child Preschool 030211 gastroenterology & hepatology Colitis Ulcerative Female business |
| Zdroj: | Scandinavian journal of gastroenterology. 53(4) |
| ISSN: | 1502-7708 |
| Popis: | OBJECTIVES Onset of microscopic colitis (MC) in patients with ulcerative colitis (UC) or Crohn's disease (CD), or vice versa, has been reported occasionally but the subject is not well described. We therefore report a retrospective observational study of such patients and review the literature. METHODS Forty-six Swedish gastroenterology clinics were contacted about patients with diagnoses of both inflammatory bowel disease (IBD) and MC. Publications were searched on PubMed. RESULTS We identified 31 patients with onset of MC after a median (range) of 20 (2-52) years after diagnosis of IBD, or vice versa; 21 UC patients developed collagenous colitis (CC) (n = 16) or lymphocytic colitis (LC) (n = 5); nine CD patients developed CC (n = 5) or LC (n = 4); one CC patient developed CD. Of the 21 UC patients, 18 had extensive disease, whereas no consistent phenotype occurred in CD. Literature review revealed 27 comprehensive case reports of patients with diagnoses of both IBD and MC. Thirteen MC patients developed IBD, of which four required colectomy. Fourteen IBD patients later developed MC. There were incomplete clinical data in 115 additional reported patients. CONCLUSIONS Altogether 173 patients with occurrence of both IBD and MC were found. The most common finding in our patients was onset of CC in a patient with UC. Although these are likely random associations of two different disorders, MC should be considered in the patient with UC or CD if there is onset of chronic watery diarrhoea without endoscopic relapse of IBD. |
| Databáze: | OpenAIRE |
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