Severe hyperphosphatasemia and severe acute respiratory syndrome coronavirus 2 infection in children
| Autor: | Loic Hery, Sandrine Castelain, Fiorella Caron, Bernard Romeo, Karine Braun, Adeline Ferec, Hyppolite K. Tchidjou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Coronavirus disease 2019 (COVID-19) viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral 030204 cardiovascular system & hematology medicine.disease_cause Betacoronavirus 03 medical and health sciences Hyperphosphatemia COVID-19 Testing 0302 clinical medicine medicine Humans Pandemics Tropism Coronavirus Clinical Laboratory Techniques Reverse Transcriptase Polymerase Chain Reaction SARS-CoV-2 business.industry COVID-19 Infant Hematology General Medicine Viral Load Alkaline Phosphatase medicine.disease Natural history Pneumonia France Coronavirus Infections business Viral load 030215 immunology |
| Zdroj: | Blood Coagulation & Fibrinolysis |
| ISSN: | 1473-5733 0957-5235 |
| DOI: | 10.1097/mbc.0000000000000954 |
| Popis: | It is now known that SARS-CoV-2 infection because of coronavirus is highly contagious and caused varying degrees of illness throughout the world. Hepatic dysfunction and the slight elevation of liver enzymes have been reported in cases of COVID-19 infection. Transient hyperphosphatasemia is a benign condition characterized by the elevation of serum alkaline phosphatase and the return to normal levels within weeks or months of first observation. We reported the first infant case of severe hyperphosphatasemia because of SARS-CoV-2 infection, in a 9-month-old child admitted to the Pediatric Covid-19 Unit of Amiens University Hospital. Given the hepatic tropism and COVID-19-related hyperinflammatory reactions, our case suggests that, an isolated severe hyperphosphatasemia in children with SARS-CoV-2 infection should increase the possibility of transient hyperphosphatasemia, even if is also demonstrated a classic natural history of the transient hyperphosphatasemia during viral infection, especially in SARS-CoV-2 infection. |
| Databáze: | OpenAIRE |
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