In-vivo antimalarial activity of **Cassia occidentalis**, **Morinda morindoides** and **Phyllanthus niruri**
| Autor: | Sandra Apers, Arnold J. Vlietinck, L. Tona, Nina Hermans, T. De Bruyne, J. Totté, B Chrimwami, K. Mesia, Luc Pieters, K. Cimanga, Okond'ahoka, N.P. Ngimbi |
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| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Phyllanthus
biology Traditional medicine 040301 veterinary sciences 030231 tropical medicine Biological activity 04 agricultural and veterinary sciences biology.organism_classification law.invention 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Infectious Diseases In vivo law Cassia Morinda morindoides visual_art visual_art.visual_art_medium Parasitology Bark Plasmodium berghei Phytotherapy |
| Zdroj: | Annals of tropical medicine and parasitology |
| ISSN: | 0003-4983 |
| Popis: | The ethanolic, dichloromethane and lyophilized aqueous extracts of Cassia occidentalis root bark, Morinda morindoides leaves and whole plants of Phyllanthus niruri were evaluated for their antimalarial actvity in vivo, in 4-day, suppressive assays against Plasmodium berghei ANKA in mice. No toxic effect or mortality was observed in mice treated, orally, with any of the extracts as a single dose, of 500 mg/kg body weight, or as the same dose given twice weekly for 4 weeks (to give a total dose of 4 g/kg). No significant lesions were observed, by eye or during histopathological examinations, in the hearts, lungs, spleens, kidneys, livers, large intestines or brains of any mouse. At doses of 200 mg/kg, all the ethanolic and dichloromethane extracts produced significant chemosuppressions of parasitaemia (of > 60% for C. occidentalis root bark and Ph. niruri whole plant, and of 30% for M. morindoides leaves) when administered orally. The most active ethanolic extract, that of Ph. niruri, reduced parasitaemia by 73%. The dichloromethane extracts of M. morindoides and Ph. niruri produced similar reductions (74% and 72% chemosuppression, respectively), whereas that of C. occidentalis was slightly less active (60% chemosuppression). Each lyophilized aqueous extract was less active than the corresponding ethanolic extract. |
| Databáze: | OpenAIRE |
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