Alpha 2-adrenoceptor-mediated inhibition of prolactin release in suckling- or fenfluramine-induced hyperprolactinemia
| Autor: | P. Navarra, P. Preziosi, E. Lacroix, W. Eechaute |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Fenfluramine Endocrinology Diabetes and Metabolism Clinical Biochemistry Radioimmunoassay Alpha (ethology) Biology Serotonergic Biochemistry Endocrinology Lactation Internal medicine medicine Animals Adrenergic alpha-Antagonists Biochemistry (medical) Rats Inbred Strains General Medicine Receptors Adrenergic alpha Prolactin Clonidine Yohimbine Animals Suckling Rats Hyperprolactinemia medicine.anatomical_structure Female Idazoxan Adrenergic alpha-Agonists hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 23(5) |
| ISSN: | 0018-5043 |
| Popis: | It has recently been shown that the specific and selective alpha 2-antagonist idazoxan (IDZ) displays prolactin-lowering activity on hyperprolactinemia induced in the rat either by suckling or serotonergic drugs. In an attempt better to understand the role of alpha 2-adrenoceptors under the above conditions, experiments were carried out to compare the effects of IDZ with that of the classic alpha 2-antagonist yohimbine (YOH), and also of the alpha 2-agonists clonidine (CLO) and B-HT 920, on prolactin (PRL) release during lactation and in hyperprolactinemia induced in male rats by the serotonergic drug fenfluramine (FEN). In lactating rats, both alpha 2-agonists decreased PRL release; this effect was enhanced by prior separation of the animals from their pups for several hours. A decrease of plasma PRL levels was also induced by IDZ but not by YOH, which tended further to increase hyperprolactinemia. In male rats treated with FEN, IDZ and CLO, a significant decrease of plasma PRL was produced, but YOH further enhanced PRL secretion. It is concluded that the alpha 2-agonists tested and also the alpha 2-antagonist IDZ display a unique inhibitory activity on PRL release during suckling or serotonergic-induced hyperprolactinemia. |
| Databáze: | OpenAIRE |
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