Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?
| Autor: | Tao Gan, Shanshan An, Sirui Yan, Qiuyun Liu, Huan Xu, Ying Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Calcium oxalate
Glycine chemistry.chemical_element 030204 cardiovascular system & hematology Calcium lcsh:RC254-282 Divalent 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Valine valine Neoplasms Tumor Microenvironment Medicine Neoplasm Humans chemistry.chemical_classification Commentary & View calcium Calcium Oxalate business.industry tumorigenic microenvironment Hematology General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Amino acid Oncology chemistry Biochemistry 030220 oncology & carcinogenesis Dietary Supplements tumor-suppressive microenvironment business DNA |
| Zdroj: | Cancer Control : Journal of the Moffitt Cancer Center Cancer Control, Vol 27 (2020) |
| ISSN: | 1526-2359 1073-2748 |
| Popis: | A tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent cations such as calcium. We hypothesize that the formation of insoluble and rigid calcium oxalate augmented by glycine and valine counteracts strong acids such as HCl chemically, thus reducing cancer risks. The anticancer effects of the 2 amino acids can be explained from a chemical and biochemical perspective. A tumor-suppressive microenvironment could be established via the modification of the proteome without genome editing at the DNA level. |
| Databáze: | OpenAIRE |
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