BDNF Exerts Contrasting Effects on Peripheral Myelination of NGF-Dependent and BDNF-Dependent DRG Neurons
| Autor: | Selma K. Kaasinen, Trevor J. Kilpatrick, Melanie Willingham, Ulrich Putz, Jason Howitt, Ian A. Hendry, Simon S. Murray, Junhua Xiao, Agnes W. Wong, Graham L. Barrett |
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| Rok vydání: | 2009 |
| Předmět: |
Carbazoles
Schwann cell Nerve Tissue Proteins Receptors Nerve Growth Factor Tropomyosin receptor kinase B Biology Transfection Indole Alkaloids Animals Genetically Modified Rats Sprague-Dawley Tissue Culture Techniques Mice Dorsal root ganglion Neurotrophic factors Ganglia Spinal Nerve Growth Factor medicine Animals Humans Low-affinity nerve growth factor receptor Receptors Growth Factor Enzyme Inhibitors Cells Cultured Neurons Brain-derived neurotrophic factor Myelin-associated glycoprotein Brain-Derived Neurotrophic Factor General Neuroscience Myelin Basic Protein Coculture Techniques Rats Myelin-Associated Glycoprotein medicine.anatomical_structure Nerve growth factor Animals Newborn Gene Expression Regulation nervous system Schwann Cells Brief Communications Myelin P0 Protein Neuroscience Myelin Proteins |
| Zdroj: | The Journal of Neuroscience. 29:4016-4022 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.3811-08.2009 |
| Popis: | Although brain-derived neurotrophic factor (BDNF) has been shown to promote peripheral myelination during development and remyelination after injury, the precise mechanisms mediating this effect remain unknown. Here, we determine that BDNF promotes myelination of nerve growth factor-dependent neurons, an effect dependent on neuronal expression of the p75 neurotrophin receptor, whereas BDNF inhibits myelination of BDNF-dependent neurons via the full-length TrkB receptor. Thus, BDNF exerts contrasting effects on Schwann cell myelination, depending on the complement of BDNF receptors that are expressed by different subpopulations of dorsal root ganglion neurons. These results demonstrate that BDNF exerts contrasting modulatory roles in peripheral nervous system myelination, and that its mechanism of action is acutely regulated and specifically targeted to neurons. |
| Databáze: | OpenAIRE |
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