Prediction of Motor Recovery Using Initial Impairment and fMRI 48 h Poststroke
| Autor: | Eric Zarahn, Leeor Alon, Randolph S. Marshall, Sophia L. Ryan, Cornelius Weiller, John W. Krakauer, Ronald M. Lazar, Magnus Sebastian Vry |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Total sum of squares Cognitive Neuroscience Motor Activity Disability Evaluation Cellular and Molecular Neuroscience Physical medicine and rehabilitation Task Performance and Analysis medicine Humans Stroke medicine.diagnostic_test Magnetic resonance imaging Recovery of Function Articles Middle Aged Models Theoretical medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Hemiparesis Ischemic stroke Upper limb Female Motor recovery medicine.symptom Functional magnetic resonance imaging Psychology |
| Zdroj: | Cerebral Cortex. 21:2712-2721 |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhr047 |
| Popis: | There is substantial interpatient variation in recovery from upper limb impairment after stroke in patients with severe initial impairment. Defining recovery as a change in the upper limb Fugl-Meyer score (ΔFM), we predicted ΔFM with its conditional expectation (i.e., posterior mean) given upper limb Fugl-Meyer initial impairment (FM(ii)) and a putative functional magnetic resonance imaging (fMRI) recovery measure. Patients with first time, ischemic stroke were imaged at 2.5 ± 2.2 days poststroke with 1.5-T fMRI during a hand closure task alternating with rest (fundamental frequency = 0.025 Hz, scan duration = 172 s). Confirming a previous finding, we observed that the prediction of ΔFM by FM(ii) alone is good in patients with nonsevere initial hemiparesis but is not good in patients with severe initial hemiparesis (96% and 16% of the total sum of squares of ΔFM explained, respectively). In patients with severe initial hemiparesis, prediction of ΔFM by the combination of FM(ii) and the putative fMRI recovery measure nonsignificantly increased predictive explanation from 16% to 47% of the total sum of squares of ΔFM explained. The implications of this preliminary negative result are discussed. |
| Databáze: | OpenAIRE |
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