In Vitro and In Vivo Antioxidant and Anti-Hyperglycemic Activities of Moroccan Oat Cultivars
| Autor: | My El Abbes Faouzi, Layachi Chabraoui, Bouchra Meddah, El Mostafa Karym, Nezha Saidi, Azlarab Masrar, Yahia Cherrah, Ilias Marmouzi, Mourad Kharbach, Mounya Bouabdellah, Khalid El Allali |
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| Přispěvatelé: | Analytical Chemistry and Pharmaceutical Technology, Faculty of Medicine and Pharmacy |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
digestive enzyme Antioxidant Physiology streptozotocin-nicotinamide medicine.medical_treatment Clinical Biochemistry hybrid Oat Mixed inhibition Pharmacology medicine.disease_cause Biochemistry Article Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound medicine anti-hyperglycemic Molecular Biology chemistry.chemical_classification biology Glutathione peroxidase lcsh:RM1-950 food and beverages Cell Biology Glutathione Malondialdehyde lcsh:Therapeutics. Pharmacology 030104 developmental biology chemistry Catalase biology.protein Oxidative stress |
| Zdroj: | Antioxidants; Volume 6; Issue 4; Pages: 102 Antioxidants Antioxidants, Vol 6, Iss 4, p 102 (2017) |
| ISSN: | 2076-3921 |
| DOI: | 10.3390/antiox6040102 |
| Popis: | Improvement of oat lines via introgression is an important process for food biochemical functionality. This work aims to evaluate the protective effect of phenolic compounds from hybrid Oat line (F11-5) and its parent (Amlal) on hyperglycemia-induced oxidative stress and to establish the possible mechanisms of antidiabetic activity by digestive enzyme inhibition. Eight phenolic acids were quantified in our samples including ferulic, p-hydroxybenzoic, caffeic, salicylic, syringic, sinapic, p-coumaric and chlorogenic acids. The Oat extract (2000 mg/kg) ameliorated the glucose tolerance, decreased Fasting Blood Glucose (FBG) and oxidative stress markers, including Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Glutathione (GSH) and Malondialdehyde (MDA) in rat liver and kidney. Furthermore, Metformin and Oat intake prevented anxiety, hypercholesterolemia and atherosclerosis in diabetic rats. In vivo anti-hyperglycemic effect of Oat extracts has been confirmed by their inhibitory activities on α-amylase (723.91 μg/mL and 1027.14 μg/mL) and α-glucosidase (1548.12 μg/mL & 1803.52 μg/mL) enzymes by mean of a mixed inhibition. |
| Databáze: | OpenAIRE |
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