The Emerging Role of Neutrophil Granulocytes in Multiple Sclerosis
| Autor: | Sophie E. Bouffler, Alicia S. Wilson, Anne Brüstle, Tonia Woodberry, Rebecca L. Buckland |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Central nervous system lcsh:Medicine Review Disease multiple sclerosis Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system neutrophils Demyelinating disease medicine treatment EAE business.industry Multiple sclerosis lcsh:R NETs General Medicine medicine.disease Phenotype 030104 developmental biology medicine.anatomical_structure Immunology business 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 7, Iss 12, p 511 (2018) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm7120511 |
| Popis: | Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a strong autoimmune, neurodegenerative, and neuroinflammatory component. Most of the common disease modifying treatments (DMTs) for MS modulate the immune response targeting disease associated T and B cells and while none directly target neutrophils, several DMTs do impact their abundance or function. The role of neutrophils in MS remains unknown and research is ongoing to better understand the phenotype, function, and contribution of neutrophils to both disease onset and stage of disease. Here we summarize the current state of knowledge of neutrophils and their function in MS, including in the rodent based MS model, and we discuss the potential effects of current treatments on these functions. We propose that neutrophils are likely to participate in MS pathogenesis and their abundance and function warrant monitoring in MS. |
| Databáze: | OpenAIRE |
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