Seminoma testis with elevated serum beta-HCG--a category of germ-cell cancer between seminoma and nonseminoma
| Autor: | Klaus-Peter Dieckmann, W. Düe, H. W. Bauer |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Nephrology
Adult Male medicine.medical_specialty Urology medicine.medical_treatment Dysgerminoma Chorionic Gonadotropin Diagnosis Differential Testicular Neoplasms Internal medicine medicine Biomarkers Tumor Humans Chorionic Gonadotropin beta Subunit Human Testicular cancer Retrospective Studies business.industry Induction chemotherapy Seminoma Middle Aged medicine.disease Peptide Fragments Surgery Radiation therapy Spermatocytic seminoma Differential diagnosis business |
| Zdroj: | International urology and nephrology. 21(2) |
| ISSN: | 0301-1623 |
| Popis: | Serum beta-HCG was elevated in 10 of 83 consecutive patients with histologically pure seminoma (12%). Six patients with diagnostic stage I were successfully treated by radiation therapy. One patient with state IIc suffered a mediastinal relapse following retroperitoneal radiotherapy. Two other patients with high tumour burden achieved complete remission after induction chemotherapy followed by surgery and radiotherapy, respectively. One patient with retroperitoneal bulky disease reached permanent complete remission after radiation therapy alone. Beta-HCG-positive seminomas constitute a distinct category of germ-cell tumours on the basis of morphological and clinical features. Corresponding to the intermediate histological position between seminoma and nonseminoma, safe treatment of beta-HCG-positive seminoma can be achieved by radiotherapy in stage I, by retroperitoneal lymphadenectomy plus adjuvant chemotherapy in stages IIa, b and by induction chemotherapy in stages IIc and III. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink