The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids
| Autor: | Mohammad S. Siddiqui, Hae-Ki Min, Andrew Joyce, Arun J. Sanyal, Rohit Kohli, Prasanna K. Santhekadur, Sophie C. Cazanave, Puneet Puri, Divya P. Kumar, Michael O. Idowu, Kalyani Daita, Melissa J. Contos, Velimir A. Luketic, Phillip B. Hylemon, Huiping Zhou, Sherry Boyett, Faridoddin Mirshahi |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Liver Cirrhosis Male 0301 basic medicine medicine.medical_specialty Cirrhosis Receptors Cytoplasmic and Nuclear Type 2 diabetes Severity of Illness Index digestive system Bile Acids and Salts 03 medical and health sciences Insulin resistance Non-alcoholic Fatty Liver Disease Internal medicine Nonalcoholic fatty liver disease medicine Humans Prospective Studies Chenodeoxycholate Aged Hepatology Chemistry Fatty liver nutritional and metabolic diseases Middle Aged medicine.disease digestive system diseases Cross-Sectional Studies 030104 developmental biology Endocrinology Female Steatosis Steatohepatitis |
| Zdroj: | Hepatology. 67:534-548 |
| ISSN: | 1527-3350 0270-9139 |
| Popis: | The histologic spectrum of nonalcoholic fatty liver disease (NAFLD) includes fatty liver (NAFL) and steatohepatitis (NASH), which can progress to cirrhosis in up to 20% NASH patients. Bile acids (BA) are linked to pathogenesis and therapy of NASH. We (a) characterized plasma BA profile in biopsy proven NAFL and NASH, and compared to controls, and (b) related plasma BA profile to liver histologic features, disease activity and fibrosis. Liquid chromatography/mass spectrometry quantified BAs. Descriptive statistics, paired and multiple group comparisons, and regression analyses were performed. Eighty six patients (24 controls, 25 NAFL and 37 NASH, mean age 51.8 years and BMI 31.9 kg/m2), 66% were women. Increased total primary BAs and decreased secondary BAs (both p |
| Databáze: | OpenAIRE |
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