Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa
| Autor: | Antoine Jaquet, Apollinaire Horo, Didier K Ekouevi, Badian Toure, Patrick A Coffie, Benjamin Effi, Severin Lenaud, Eugene Messou, Albert Minga, Annie J Sasco, François Dabis, IeDEA West Africa Collaboration |
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| Rok vydání: | 2013 |
| Předmět: |
Health Screening
Multivariate analysis Non-Clinical Medicine Gynecologic Infections lcsh:Medicine Uterine Cervical Neoplasms HIV Infections Cervix Uteri Cervical Cancer West africa 0302 clinical medicine Risk Factors Cancer screening 030212 general & internal medicine lcsh:Science Cervical cancer Colposcopy Multidisciplinary medicine.diagnostic_test Obstetrics Cancer Risk Factors virus diseases Obstetrics and Gynecology HIV diagnosis and management Middle Aged 3. Good health Vaccination AIDS Anti-Retroviral Agents Oncology HIV epidemiology 030220 oncology & carcinogenesis Medicine Infectious diseases Female Public Health Cancer Screening Research Article Adult medicine.medical_specialty Human Papillomavirus Infection Sexually Transmitted Diseases Viral diseases Cervical intraepithelial neoplasia 03 medical and health sciences medicine Antiretroviral treatment Cancer Detection and Diagnosis Humans Cervical Intraepithelial Neoplasia Gynecology Health Care Policy business.industry lcsh:R Gynecologic Cancers HIV Cancers and Neoplasms medicine.disease Uterine Cervical Dysplasia CD4 Lymphocyte Count Cote d'Ivoire lcsh:Q business Gynecological Tumors Screening Guidelines |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 3, p e90625 (2014) Jaquet, A, Horo, A, Ekouevi, D K, Toure, B, Coffie, P A, Effi, B, Lenaud, S, Messou, E, Minga, A, Sasco, A J, Dabis, F & IeDEA West Africa Collaboration (Lars Østergaard, Christian Wejse members) 2014, ' Risk factors for cervical intraepithelial neoplasia in HIV-infected women on antiretroviral treatment in Côte d'Ivoire, West Africa ', PLOS ONE, vol. 9, no. 3, pp. e90625 . https://doi.org/10.1371/journal.pone.0090625 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0090625 |
| Popis: | BACKGROUND: Facing the dual burden of invasive cervical cancer and HIV in sub-Saharan Africa, the identification of preventable determinants of Cervical Intraepithelial Neoplasia (CIN) in HIV-infected women is of paramount importance.METHODS: A cervical cancer screening based on visual inspection methods was proposed to HIV-infected women in care in Abidjan, Côte d'Ivoire. Positively screened women were referred for a colposcopy to a gynaecologist who performed directed biopsies.RESULTS: Of the 2,998 HIV-infected women enrolled, 132 (4.4%) CIN of any grade (CIN+) were identified. Women had been followed-up for a median duration of three years [IQR: 1-5] and 76% were on antiretroviral treatment (ART). Their median most recent CD4 count was 452 [IQR: 301-621] cells/mm3. In multivariate analysis, CIN+ was associated with a most recent CD4 count >350 cells/mm3 (OR: 0.3; 95% CI: 0.2-0.6) or ≥200-350 cells/mm3 (OR 0.6; 95% CI 0.4-1.0) (Ref: CONCLUSIONS: The presence of CIN+ is less common among HIV-infected women with limited or no immune deficiency. Despite the potential impact of immunological recovery on the reduction of premalignant cervical lesions through the use of ART, cervical cancer prevention, including screening and vaccination remains a priority in West Africa while ART is rolled-out. |
| Databáze: | OpenAIRE |
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