Relationship between Younger Age, Autoimmunity, Cardiometabolic Risk, Oxidative Stress, HAART, and Ischemic Stroke in Africans with HIV/AIDS
| Autor: | Bertrand Ellenga-Mbolla, Augustin Nge Okwe, Benjamin Longo-Mbenza, Simon Mbungu Fuele, Murielle Longokolo Mashi, Nelly Kangola Kabangu, Thierry Raoul Gombet, Michel Lelo Tshikwela, Etienne Mokondjimobe |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Younger age Article Subject business.industry Disease medicine.disease medicine.disease_cause Autoimmunity Acquired immunodeficiency syndrome (AIDS) Internal medicine Ischemic stroke medicine Physical therapy Metabolic syndrome business Stroke Oxidative stress Research Article |
| Zdroj: | ISRN Cardiology |
| ISSN: | 2090-5580 |
| DOI: | 10.5402/2011/897908 |
| Popis: | Background and Purpose. It now appears clear that both HIV/AIDS and antiretroviral therapy (HAART) use are associated with higher risk of cardiovascular disease such as stroke. In this study, we evaluated the prevalence, the risk factors, and the cardiometabolic comorbidities of stroke in HIV/AIDS Central African patients. Methods. This hospital-based cross-sectional study collected clinical, laboratory, and imaging data of black Central African heterosexual, intravenous drug nonuser, and HIV/AIDS patients. Results. There were 54 men and 62 women, with a female to male ratio of 1.2 : 1. All were defined by hypercoagulability and oxidative stress. Hemorrhagic stroke was reported in 1 patient, ischemic stroke in 17 patients, and all stroke subtypes in 18 patients (15%). Younger age Conclusions. Clustering of several cardiometabolic factors, autoimmunity, oxidative stress, and lifestyle changes may explain accelerated atherosclerosis and high risk of stroke in these young black Africans with HIV/AIDS. Prevention and intervention programs are needed. |
| Databáze: | OpenAIRE |
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