Association of cycling with all-cause and cardiovascular disease mortality among persons with diabetes: The European Prospective Investigation Into Cancer and Nutrition (EPIC) study
| Autor: | W M Monique Verschuren, Matthias B. Schulze, Kim Overvad, Giovanna Masala, Valeria Pala, Sandra Colorado-Yohar, Raul Zamora-Ros, Kristina E.N. Petersen, Eva Ardanaz, Dagfinn Aune, Manuela M. Bergmann, Kostas Tsilidis, Heinz Freisling, Keren Papier, Nicholas J. Wareham, Alicia K Heath, Karen Steindorf, Anders Grøntved, Kim Blond, Annemieke M.W. Spijkerman, Thure Filskov Overvad, Martin Gillies Rasmussen, Lars Bo Andersen, Julie L M Andersen, Verena Katzke, Soren Brage, Elisabete Weiderpass, Mathias Ried-Larsen, Salvatore Panico |
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| Přispěvatelé: | Wareham, Nicholas [0000-0003-1422-2993], Brage, Soren [0000-0002-1265-7355], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty SHORT-TERM EXPOSURE EXERCISE Transportation HEART-DISEASE Lower risk US ADULTS Risk Factors Diabetes mellitus Internal medicine Cause of Death Neoplasms Internal Medicine Diabetes Mellitus Medicine Humans Medical history LIFE EXPECTANCY Prospective Studies Prospective cohort study Exercise Original Investigation business.industry Hazard ratio LEISURE-TIME AIR-POLLUTION Middle Aged medicine.disease European Prospective Investigation into Cancer and Nutrition Bicycling MEDITERRANEAN DIET Europe Survival Rate PHYSICAL-ACTIVITY Nutrition Assessment Cardiovascular Diseases RISK-FACTORS Female business Cycling Cohort study Follow-Up Studies |
| Zdroj: | Ried-Larsen, M, Rasmussen, M G, Blond, K, Overvad, T F, Overvad, K, Steindorf, K, Katzke, V, Andersen, J L M, Petersen, K E N, Aune, D, Tsilidis, K K, Heath, A K, Papier, K, Panico, S, Masala, G, Pala, V, Weiderpass, E, Freisling, H, Bergmann, M M, Verschuren, W M M, Zamora-Ros, R, Colorado-Yohar, S M, Spijkerman, A M W, Schulze, M B, Ardanaz, E M A, Andersen, L B, Wareham, N, Brage, S & Grøntved, A 2021, ' Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes : The European Prospective Investigation Into Cancer and Nutrition (EPIC) Study ', JAMA Internal Medicine, vol. 181, no. 9, pp. 1196-1205 . https://doi.org/10.1001/jamainternmed.2021.3836 Ried-Larsen, M, Rasmussen, M G, Blond, K, Overvad, T F, Overvad, K, Steindorf, K, Katzke, V, Andersen, J L M, Petersen, K E N, Aune, D, Tsilidis, K K, Heath, A K, Papier, K, Panico, S, Masala, G, Pala, V, Weiderpass, E, Freisling, H, Bergmann, M M, Verschuren, W M M, Zamora-Ros, R, Colorado-Yohar, S M, Spijkerman, A M W, Schulze, M B, Ardanaz, E M A, Andersen, L B, Wareham, N, Brage, S & Grøntved, A 2021, ' Association of Cycling with All-Cause and Cardiovascular Disease Mortality among Persons with Diabetes : The European Prospective Investigation into Cancer and Nutrition (EPIC) Study ', JAMA Internal Medicine, vol. 181, no. 9, pp. 1196-1205 . https://doi.org/10.1001/jamainternmed.2021.3836 JAMA Intern Med |
| Popis: | Importance: Premature death from all causes and cardiovascular disease (CVD) causes is higher among persons with diabetes.Objective: To investigate the association between time spent cycling and all-cause and CVD mortality among persons with diabetes, as well as to evaluate the association between change in time spent cycling and risk of all-cause and CVD mortality.Design, Setting, and Participants: This prospective cohort study included 7459 adults with diabetes from the European Prospective Investigation into Cancer and Nutrition study. Questionnaires regarding medical history, sociodemographic, and lifestyle information were administered in 10 Western European countries from 1992 through 2000 (baseline examination) and at a second examination 5 years after baseline. A total of 5423 participants with diabetes completed both examinations. The final updated primary analysis was conducted on November 13, 2020.Exposures: The primary exposure was self-reported time spent cycling per week at the baseline examination. The secondary exposure was change in cycling status from baseline to the second examination.Main Outcomes and Measures: The primary and secondary outcomes were all-cause and CVD mortality, respectively, adjusted for other physical activity modalities, diabetes duration, and sociodemographic and lifestyle factors.Results: Of the 7459 adults with diabetes included in the analysis, the mean (SD) age was 55.9 (7.7) years, and 3924 (52.6%) were female. During 110 944 person-years of follow-up, 1673 deaths from all causes were registered. Compared with the reference group of people who reported no cycling at baseline (0 min/wk), the multivariable-adjusted hazard ratios for all-cause mortality were 0.78 (95% CI, 0.61-0.99), 0.76 (95% CI, 0.65-0.88), 0.68 (95% CI, 0.57-0.82), and 0.76 (95% CI, 0.63-0.91) for cycling 1 to 59, 60 to 149, 150 to 299, and 300 or more min/wk, respectively. In an analysis of change in time spent cycling with 57 802 person-years of follow-up, a total of 975 deaths from all causes were recorded. Compared with people who reported no cycling at both examinations, the multivariable-adjusted hazard ratios for all-cause mortality were 0.90 (95% CI, 0.71-1.14) in those who cycled and then stopped, 0.65 (95% CI, 0.46-0.92) in initial noncyclists who started cycling, and 0.65 (95% CI, 0.53-0.80) for people who reported cycling at both examinations. Similar results were observed for CVD mortality.Conclusion and Relevance: In this cohort study, cycling was associated with lower all-cause and CVD mortality risk among people with diabetes independent of practicing other types of physical activity. Participants who took up cycling between the baseline and second examination had a considerably lower risk of both all-cause and CVD mortality compared with consistent noncyclists. |
| Databáze: | OpenAIRE |
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