Plasma Levels of Tumor Necrosis Factor in Patients with Mediterranean Spotted Fever: Clinical and Analytical Correlations
| Autor: | J. Oristrell, F. Segura-Porta, B. Font-Creus, M. {a. } J. Amengual, A. Casanovas |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Sodium chemistry.chemical_element Enzyme-Linked Immunosorbent Assay Boutonneuse Fever Gastroenterology Internal medicine Blood plasma medicine Humans Aged Aged 80 and over biology Tumor Necrosis Factor-alpha business.industry C-reactive protein Plasma levels Middle Aged medicine.disease Spotted fever Boutonneuse fever C-Reactive Protein Infectious Diseases Rickettsiosis chemistry Acute Disease Immunology biology.protein Female Tumor necrosis factor alpha business |
| Zdroj: | Clinical Infectious Diseases. 19:1141-1143 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Twenty consecutive patients with serologically confirmed Mediterranean spotted fever were analyzed for determination of plasma levels of tumor necrosis factor alpha (TNF-alpha) by means of an ELISA. Increased levels of TNF-alpha in plasma were found during the acute phase of the disease (52.3 +/- 49.8 pg/mL) compared to levels in the convalescent phase (9.0 +/- 9.3 pg/mL; P < .001) or in healthy controls (6.5 +/- 3.2 pg/mL; P < .001). Plasma TNF-alpha levels were significantly higher in patients with severe Mediterranean spotted fever. Levels of TNF-alpha correlated significantly with serum levels of C-reactive protein and triglycerides and inversely with serum levels of sodium. |
| Databáze: | OpenAIRE |
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