A prospective study of tumor recurrence and the acute-phase response after apparently curative colorectal cancer surgery
| Autor: | Heather A. Wotherspoon, Catherine Sturgeon, C S McArdle, Donald C. McMillan, Kenneth C. H. Fearon, T. G. Cooke |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer Rectum Gastroenterology Carcinoembryonic antigen Internal medicine medicine Humans Prospective Studies Neoplasm Metastasis Acute-Phase Reaction Prospective cohort study Aged Neoplasm Staging Aged 80 and over biology business.industry C-reactive protein Acute-phase protein General Medicine Middle Aged medicine.disease Colorectal surgery Carcinoembryonic Antigen Tumor recurrence Surgery C-Reactive Protein Treatment Outcome medicine.anatomical_structure biology.protein Female Neoplasm Recurrence Local Colorectal Neoplasms business |
| Zdroj: | The American Journal of Surgery. 170:319-322 |
| ISSN: | 0002-9610 |
| Popis: | Background: Approximately 70% of patients who are going to develop tumor recurrence following curative colorectal surgery do so within 24 months of surgery. Patients and methods: The relationship was prospectively examined between an ongoing acute-phase response and subsequent clinical relapse in 36 colorectal cancer patients who had undergone a curative resection. Approximately 4 months after their operation, patients were grouped according to the presence (n = 15) or absence (n = 21) of an acute-phase response (C-reactive protein >5 mg/L) and were followed-up for a minimum of 24 months. Results: Age, tumor site, and serum carcinoembryonic antigen concentrations were similar in both groups. There was a significantly higher recurrence rate in patients with an acute-phase response (11 of 15) compared to those with no acute-phase response (2 of 21, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect