Effects of different inspired oxygen fractions on sildenafil-induced pulmonary anti-hypertensive effects in a sheep model of acute pulmonary embolism
| Autor: | Francisco J. Teixeira-Neto, Nathalia Celeita Rodríguez, Miriely Steim-Diniz, Angie Paola Lagos-Carvajal, Carlos A. Dias-Junior, D. R. B. Velásquez |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Sildenafil Hypertension Pulmonary chemistry.chemical_element Blood Pressure Placebo Oxygen Piperazines Sildenafil Citrate General Biochemistry Genetics and Molecular Biology Acute pulmonary embolism Pulmonary hypertension chemistry.chemical_compound Heart Rate Internal medicine medicine Animals Pulmonary Wedge Pressure Cardiac Output General Pharmacology Toxicology and Pharmaceutics Antihypertensive Agents Sulfonamides Sheep business.industry General Medicine Oxygenation medicine.disease Pulmonary embolism chemistry Purines Concomitant Anesthesia Respiratory Mechanics Room air distribution Cardiology Vascular Resistance Pulmonary Embolism business |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2015-10-21T13:08:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-04-15 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Aims: Sildenafil is a pulmonary anti-hypertensive agent whose action could be modified by different fractions of inspired oxygen (FiO(2)). We compared the effects of pure oxygen (FiO(2) > 90%) or room air (21% FiO(2)) on the cardiopulmonary actions of sildenafil in sheep with acute pulmonary embolism (APE).Main methods: Forty anesthetized, mechanically ventilated sheep (34.9 +/- 5.4 kg), were randomly distributed into four groups (n = 4 per group): FiO(2) > 90% without intervention; APE induced by microspheres with FiO(2) > 90%, followed 30 min later by placebo (Emb(90)); or APE followed 30 min later by intravenous sildenafil (0.7 mg/kg over 30 min) with FiO(2) > 90% (Emb + Sild(90)) or 21% FiO(2) (Emb + Sild(21)). Variables were recorded until 30 min after the end of treatment administration.Key findings: Microsphere injection increased (P < 0.05) mean pulmonary artery pressure (MPAP) in all embolized groups (111-140% higher than that of baseline). Compared with values recorded 30 min after induction of APE (E-30), sildenafil induced greater decreases in MPAP in the Emb + Sil(90) group than in the Emb + Sil(21) group (23% and 14% lower than E-30, respectively). Hypotension (mean arterial pressure |
| Databáze: | OpenAIRE |
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