3-(4-Aminobutyn-1-yl)pyridines: binding at α4β2 nicotinic cholinergic receptors
| Autor: | Deniz Dogruer, Malgorzata Dukat, M. Imad Damaj, Richard A. Glennon, Billy R. Martin, Mase Lee |
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| Rok vydání: | 2004 |
| Předmět: |
Pyridines
Stereochemistry Chemistry Butanols Organic Chemistry Clinical Biochemistry Pharmaceutical Science Receptors Nicotinic Ligand (biochemistry) Biochemistry Chemical synthesis Rats Nicotinic agonist Cerebellum Drug Discovery Animals Molecular Medicine Cholinergic Amine gas treating Pharmacophore Receptor Molecular Biology Protein Binding Acetylcholine receptor |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 14:523-526 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2003.10.033 |
| Popis: | The binding of a series pyridylbutynylamines 6 was examined at alpha4beta2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models. |
| Databáze: | OpenAIRE |
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