Primary Cutaneous B-cell Lymphomas of the Lower Limbs: A Study of Integrin Expression in 11 Cases
| Autor: | Parant E, Brigitte Dréno, Tessier Mh, Lair G, Jumbou O |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Integrins Pathology medicine.medical_specialty Lymphoma B-Cell Skin Neoplasms Biopsy Lymphocyte Integrin Dermatology Disease hemic and lymphatic diseases Centroblasts Humans Medicine B cell Aged Skin Aged 80 and over Leg biology business.industry Possibly Worse General Medicine Middle Aged Prognosis medicine.disease Lymphoma Gene Expression Regulation Neoplastic Survival Rate medicine.anatomical_structure biology.protein Female business Rare disease |
| Zdroj: | Acta Dermato-Venereologica. 80:367-369 |
| ISSN: | 0001-5555 |
| DOI: | 10.1080/000155500459321 |
| Popis: | Primary cutaneous B-cell lymphoma is a rare disease. Among the cutaneous B lymphomas, B-cell lymphomas of the lower limbs appear as a special subgroup with a prognosis that is possibly worse than that of primary cutaneous B-cell lymphomas located on the trunk, arms or head, with more frequent relapses. In addition, some recent studies indicate that the level of expression of integrins on tumour cells could be related to the clinical course of the disease. This study reports on 14 cases of primary cutaneous B-cell lymphomas of the lower limbs and their clinical course. A study of integrin expression by tumour cells was performed in 11 of these cases. With a mean follow-up of 31 months, the study confirmed the worse prognosis of lymphomas with a predominance of centroblasts and immunoblasts (3 deaths) compared with lymphomas with a predominance of centrocytes, as well as their higher rate of recurrence (7/11). A correlation was confirmed between the course of the disease and the level of expression of lymphocyte function-associated antigen-1, intercellular adhesion molecule-1 and very late antigen-4 by tumour cells. |
| Databáze: | OpenAIRE |
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