Some effects of tripotassium dicitrato bismuthate on gastric secretion and the mucus barrier
| Autor: | K Li, J. J. Batten, J. Spencer, J. H. Baron, R. L. Sidebotham |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Proteolysis Duodenogastric Reflux chemistry.chemical_compound fluids and secretions Internal medicine Gastric mucosa medicine Organometallic Compounds Humans Pharmacology (medical) Secretion Amino Acids Aged Glycoproteins chemistry.chemical_classification Aged 80 and over Hepatology medicine.diagnostic_test business.industry Bismuthate Gastroenterology Middle Aged Anti-Ulcer Agents Mucus Gastric secretion Pepsin A Amino acid medicine.anatomical_structure Endocrinology chemistry Gastric Mucosa Mucus glycoprotein business Peptides |
| Zdroj: | Alimentary pharmacologytherapeutics. 4(5) |
| ISSN: | 0269-2813 |
| Popis: | SUMMARY The effect of tripotassium dicitrato bismuthate (De-Nol) on the breakdown of the gastric mucus barrier was investigated by measuring the output of mucus glycoprotein in pentagastrin-stimulated secretion from 13 patients before and after treatment for peptic ulcer, and by examining the accumulation of dialysable peptides and amino acids (DPAA) in stimulated secretion from ten of these patients. The accumulation of DPAA was significantly reduced after De-Nol (by 54%) and to a greater extent than was the output of mucus glycoprotein (by 27%). These observations are consistent with a decrease in the rate of breakdown of the mucus barrier as a result of De-Nol treatment. De-Nol significantly reduced pepsin output (by 32%) in the same group of patients. Comparison of the change in pepsin output with the change in accumulation of DPAA in stimulated juice indicated that De-Nol increases the resistance of the mucus barrier to acid-pepsin proteolysis and/or inhibits the secretion of amino acids and peptides from gastric mucosa. |
| Databáze: | OpenAIRE |
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