A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer’s Disease Neuropathology
| Autor: | Michael A. Sugarman, Ann C. McKee, Yorghos Tripodis, Ronald J. Killiany, Neil W. Kowall, Charles DeCarli, Michael L. Alosco, Brett Martin, Lilah M. Besser, Joseph Palmisano, Robert S. Stern, Rhoda Au, Jesse Mez, Thor D. Stein |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Aging Neurodegenerative Fluid-attenuated inversion recovery Alzheimer's Disease 0302 clinical medicine Leukoencephalopathies Vascular Cognitive Impairment/Dementia 80 and over magnetic resonance imaging Alzheimer's disease neuropathology Senile plaques Neuropathology Aged 80 and over General Neuroscience Brain General Medicine white matter hyperintensities Magnetic Resonance Imaging cerebrovascular disease Psychiatry and Mental health Clinical Psychology Alzheimer’s disease neuropathology Neurological Cardiology Cognitive Sciences Female Cerebral amyloid angiopathy Alzheimer’s disease medicine.medical_specialty Clinical Dementia Rating Clinical Sciences Arteriolosclerosis behavioral disciplines and activities Article 03 medical and health sciences Apolipoproteins E Clinical Research Alzheimer Disease Internal medicine mental disorders Acquired Cognitive Impairment medicine Dementia Humans Aged Psychiatric Status Rating Scales Neurology & Neurosurgery business.industry Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) medicine.disease Hyperintensity Brain Disorders 030104 developmental biology Logistic Models Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's disease : JAD, vol 63, iss 4 |
| Popis: | BACKGROUND White matter hyperintensities (WMH) on magnetic resonance imaging (MRI) have been postulated to be a core feature of Alzheimer's disease. Clinicopathological studies are needed to elucidate and confirm this possibility. OBJECTIVE This study examined: 1) the association between antemortem WMH and autopsy-confirmed Alzheimer's disease neuropathology (ADNP), 2) the relationship between WMH and dementia in participants with ADNP, and 3) the relationships among cerebrovascular disease, WMH, and ADNP. METHODS The sample included 82 participants from the National Alzheimer's Coordinating Center's Data Sets who had quantitated volume of WMH from antemortem FLAIR MRI and available neuropathological data. The Clinical Dementia Rating (CDR) scale (from MRI visit) operationalized dementia status. ADNP+ was defined by moderate to frequent neuritic plaques and Braak stage III-VI at autopsy. Cerebrovascular disease neuropathology included infarcts or lacunes, microinfarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy. RESULTS 60/82 participants were ADNP+. Greater volume of WMH predicted increased odds for ADNP (p = 0.037). In ADNP+ participants, greater WMH corresponded with increased odds for dementia (CDR≥1; p = 0.038). WMH predicted cerebral amyloid angiopathy, microinfarcts, infarcts, and lacunes (ps |
| Databáze: | OpenAIRE |
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