Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone
| Autor: | Justyn Ochocki, Joachim Kusz, Krzysztof Słomiak, Lilianna Chęcińska, Jolanta Nawrot-Modranka, Andrzej Łazarenkow |
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| Rok vydání: | 2018 |
| Předmět: |
Somatic cell
Hydrazine Pharmaceutical Science Antineoplastic Agents Microbial Sensitivity Tests Bacterial growth 010402 general chemistry Hydrazide 01 natural sciences Article Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound lcsh:Organic chemistry Anti-Infective Agents X-Ray Diffraction Cell Line Tumor Drug Discovery Humans Physical and Theoretical Chemistry Cell Proliferation hydrazide 3-formylchromone Molecular Structure 010405 organic chemistry Cell growth XTT-assay Organic Chemistry benzo-γ-pyrones Biological activity Hydrogen Bonding hydrazine Antimicrobial Combinatorial chemistry 0104 chemical sciences Hydrazines chemistry Chemistry (miscellaneous) Cell culture Chromones Molecular Medicine anti-proliferative activity |
| Zdroj: | Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry Molecules, Vol 23, Iss 8, p 2067 (2018) Molecules Volume 23 Issue 8 |
| ISSN: | 1420-3049 |
| Popis: | The hydrazine and hydrazide derivatives of benzo-&gamma pyrones with fluorine substituents remain an unexplored group of chemical compounds. This preliminary study reports the synthesis, structural assessment, initial microbiological screening and biological testing of the synthesized compounds on cell lines using the XTT-assay. A series of 10 novel hydrazine and hydrazide derivatives of 3-formylchromone were synthesized and their structures determined. Structural assessment consisted of elemental analysis, IR, 1H-NMR, 13C-NMR, MS and crystallographic studies. Antimicrobial activity was tested on standard strains representing different groups of microorganisms. The tested compounds were found to inhibit microbial growth. Concentrations of 0.01&ndash 1250 µ mol/L were found to influence cell proliferation, demonstrating antiproliferative and stimulation of proliferation against two cell lines: the L929 cell line (mouse fibroblast cell line) and the EA.hy926 cell line (the human umbilical vein, somatic cell hybrid). |
| Databáze: | OpenAIRE |
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