The replisome guides nucleosome assembly during DNA replication
| Autor: | Jianxun Feng, Qing Li, Wenshuo Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Nucleosome assembly Replisome component lcsh:Biotechnology Computational biology Review General Biochemistry Genetics and Molecular Biology lcsh:Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:TP248.13-248.65 Histone chaperone lcsh:QD415-436 Epigenetics lcsh:QH301-705.5 biology DNA synthesis DNA replication Chromatin Chromatin replication 030104 developmental biology Histone chemistry lcsh:Biology (General) biology.protein Replisome 030217 neurology & neurosurgery DNA |
| Zdroj: | Cell & Bioscience, Vol 10, Iss 1, Pp 1-14 (2020) Cell & Bioscience |
| ISSN: | 2045-3701 |
| DOI: | 10.1186/s13578-020-00398-z |
| Popis: | Nucleosome assembly during DNA replication is tightly coupled to ongoing DNA synthesis. This process, termed DNA replication-coupled (RC) nucleosome assembly, is essential for chromatin replication and has a great impact on both genome stability maintenance and epigenetic inheritance. This review discusses a set of recent findings regarding the role of replisome components contributing to RC nucleosome assembly. Starting with a brief introduction to the factors involved in nucleosome assembly and some aspects of the architecture of the eukaryotic replisome, we discuss studies from yeast to mammalian cells and the interactions of replisome components with histones and histone chaperones. We describe the proposed functions of replisome components during RC nucleosome assembly and discuss their impacts on histone segregation and implications for epigenetic inheritance. |
| Databáze: | OpenAIRE |
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