Serum and CSF adiponectin, leptin, and interleukin 6 levels as adipocytokines in Egyptian children with febrile seizures: a cross-sectional study
| Autor: | Eman M. Elhindawy, Mohamed A. Abdalhady, Mayy A.N. Allah, Seham F. Azab, Mohamed A. A. Almalky, Anwar A. Rass, Sawsan H. Abdellatif, Ahmed A. Elhewala, Mohamed M. A. Salam, Manal S. Arafat, Nahla A. Elsamad, A.A. Soliman, Dina T. Sarhan, Mustafa I.A. Hashem, Nagwa E. Akeel, Ezzat K. Amin |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Leptin Male medicine.medical_specialty Adipose tissue Adipokine Enzyme-Linked Immunosorbent Assay Seizures Febrile 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Adipokines Internal medicine Febrile seizure medicine Humans Prospective Studies Prospective cohort study Interleukin 6 Child Adiponectin biology adiponectin business.industry Interleukin-6 Research medicine.disease 030104 developmental biology Endocrinology Cross-Sectional Studies adipocytokines biology.protein Egypt Female business 030217 neurology & neurosurgery |
| Zdroj: | Italian Journal of Pediatrics |
| ISSN: | 1824-7288 |
| DOI: | 10.1186/s13052-016-0250-y |
| Popis: | Background A febrile seizure (FS) is the most common convulsive disorder in children. Activation of cytokine network is involved in FS pathogenesis. Adiponectin, leptin and IL-6 are the major adipocytokines secreted by fat cells. To date, only a few studies concerned the association of adipocytokines with febrile seizures. In this study, we tried to investigate serum and CSF levels of adiponectin, leptin, and interleukin-6 (IL-6); as adipocytokines, for the first time in Egyptian children with febrile seizures. Methods This was a prospective cross-sectional study included one hundred patients with febrile seizure, and matched with age, gender, 100 children with febrile illness without seizures (febrile control, FC) and 100 healthy control group (HC). Serum and cerebrospinal fluid (CSF) levels of adiponectin, leptin, and (IL-6) were measured by enzyme-linked immunosorbent assay (ELISA) method. Results Serum adiponectin was significantly higher in children with FS (16.8 ± 3.7 ug/ml) and the FC group (18.3 ± 4.3 ug/ml) compared to the HC group (9.5 ± 2.2 ug/ml); P 0.05). Serum and CSF leptin levels were significantly lower in patients with CFS compared to the SFS group (P |
| Databáze: | OpenAIRE |
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