Hypertonic saline has a prolonged effect on mucociliary clearance in adults with cystic fibrosis
| Autor: | Scott H. Donaldson, Jihong Wu, Aaron T. Trimble, David A. Waltz, William D. Bennett, A. Whitney Brown, Noah Lechtzin, Agathe Ceppe, Beth L. Laube, Kirby L. Zeman |
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| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Adolescent Cystic Fibrosis Mucociliary clearance Population Gastroenterology Cystic fibrosis 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Internal medicine Administration Inhalation medicine Humans 030212 general & internal medicine Clinical efficacy education Radionuclide Imaging Saline Solution Hypertonic education.field_of_study Cross-Over Studies business.industry food and beverages Middle Aged medicine.disease Hypertonic saline 030228 respiratory system Mucociliary Clearance Pharmacodynamics Pediatrics Perinatology and Child Health Female business Clearance rate |
| Zdroj: | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 17(5) |
| ISSN: | 1873-5010 |
| Popis: | Background Inhaled hypertonic saline (HS) has been shown to increase mucociliary clearance (MCC) and improve clinical outcomes in adults and adolescents with cystic fibrosis (CF). However, in younger children with CF, a large study failed to demonstrate clinical benefits. This discrepancy could reflect pharmacodynamic differences in the MCC response to HS in different populations. We previously demonstrated the absence of a sustained effect of HS on MCC in healthy adults and in this study sought to characterize the durability of the MCC response to HS in adults with CF. Methods At two study sites, MCC was measured in CF adults using gamma scintigraphy during three separate visits: at baseline, 15 min, and 4 h after a single dose of HS (7% NaCl, 4 mL). Particle clearance rates at these visits were used to assess the durability of the MCC response to HS. Results The average 90-minute clearance rate measured 4 h after HS was significantly increased (21.81% ± 12.8) when compared to baseline (13.77% ± 8.7, p = .048) and showed no apparent slowing relative to the rate measured 15 min after HS. While not all subjects responded to HS, the acute response strongly predicted the sustained effect in these subjects (r = 0.896, p Conclusions These results suggest that, in contrast to healthy adults, a single dose of HS has a prolonged effect on MCC in adults with CF, which lasts at least 4 h. This may explain its clinical efficacy in this population. |
| Databáze: | OpenAIRE |
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