Exercise-induced albuminuria is related to metabolic syndrome
| Autor: | Assi Milwidsky, Yaron Arbel, Talia Weinstein, Shlomo Berliner, David Zeltser, Itzhak Shapira, Dror Lahav, Shani Shenhar-Tsarfaty, Sharon Greenberg, Oholi Tovia-Brodie, Ori Rogowski, Jaffa Vered |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Cross-sectional study 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Albuminuria Humans Endothelial dysfunction Exercise Metabolic Syndrome Creatinine business.industry Middle Aged medicine.disease Endocrinology Cross-Sectional Studies chemistry Exercise Test Microalbuminuria Female medicine.symptom Metabolic syndrome business |
| Zdroj: | American journal of physiology. Renal physiology. 310(11) |
| ISSN: | 1522-1466 |
| Popis: | Microalbuminuria (MA) is a known marker for endothelial dysfunction and future cardiovascular events. Exercise-induced albuminuria (EiA) may precede the appearance of MA. Associations between EiA and metabolic syndrome (MS) have not been assessed so far. Our aim was to investigate this association in a large sample of apparently healthy individuals with no baseline albuminuria. This was a cross-sectional study of 2,027 adults with no overt cardiovascular diseases who took part in a health survey program and had no baseline MA. Diagnosis of MS was based on harmonized criteria. All patients underwent an exercise test (Bruce protocol), and urinary albumin was measured before and after the examination. Urinary albumin-to-creatinine ratio (ACR) values before and after exercise were 0.40 (0.21–0.89) and 1.06 (0.43–2.69) mg/g for median (interquartile range) respectively. A total of 394 (20%) subjects had EiA; ACR rose from normal rest values (0.79 mg/g) to 52.28 mg/g after exercise ( P < 0.001); this effect was not shown for the rest of the study population. EiA was related to higher prevalence of MS (13.8% vs. 27.1%, P < 0.001), higher metabolic equivalents ( P < 0.001), higher baseline blood pressure ( P < 0.001), and higher levels of fasting plasma glucose, triglycerides, and body mass index ( P < 0.001). Multivariate binary logistic regression model showed that subjects with MS were 98% more likely to have EiA (95% confidence interval: 1.13–3.46, P = 0.016). In conclusion, EiA in the absence of baseline MA is independently related to MS. |
| Databáze: | OpenAIRE |
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