Targeted therapy in thyroid cancer
| Autor: | Michael R. Tuttle, Iain J. Nixon, Ashok R. Shaha |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
endocrine system medicine.medical_specialty endocrine system diseases MAP Kinase Signaling System medicine.medical_treatment MEDLINE Antineoplastic Agents Targeted therapy Internal medicine medicine Humans In patient Molecular Targeted Therapy Thyroid Neoplasms Anaplastic thyroid cancer skin and connective tissue diseases Thyroid cancer Protein Kinase Inhibitors business.industry Medullary thyroid cancer Cancer medicine.disease Otorhinolaryngology Surgery sense organs business |
| Zdroj: | Current opinion in otolaryngologyhead and neck surgery. 21(2) |
| ISSN: | 1531-6998 |
| Popis: | Recent advances in the understanding of the biological basis for thyroid cancer have identified molecular changes in thyroid cancer cells. These changes form the basis for targeted therapies, which have been investigated with some success in patients with advanced, inoperable thyroid cancers and are the subject of this review.For patients with advanced differentiated thyroid cancers, sorafenib, selumetinib, pazopanib and sunitinib have been investigated with promising results. In the setting of advanced medullary thyroid cancer, vandetanib now has FDA approval, whereas sorafenib, sunitinib and cabozantinib have shown activity in early studies. For patients with anaplastic thyroid cancer, no targeted therapy has been proven to be effective in vivo, although preclinical work on various kinase inhibitors has shown promise. Despite the potential for disease response, significant cardiac, gastrointestinal and skin-related side effects are reported for all therapies, limiting their application outside the setting of incurable disease.Inoperable thyroid cancer still has a poor prognosis, however, the introduction of targeted therapies offers the hope of longer quality of meaningful life for this small group of patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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