HSPB7 gene polymorphism associated with anthropometric parameters of obesity and fat intake in a Central European population
| Autor: | Tereza Pavlová, Filip Zlámal, Julie Bienertová-Vašků, Jan Novak |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Genotype HSP27 Heat-Shock Proteins Physiology Body fat percentage 03 medical and health sciences Fat intake medicine Humans Genetic variability Obesity Polymorphism Genetic Anthropometry business.industry Public Health Environmental and Occupational Health General Medicine medicine.disease Dietary Fats Diet Europe 030104 developmental biology Cohort Gene polymorphism business |
| Zdroj: | Central European journal of public health. 26(4) |
| ISSN: | 1210-7778 |
| Popis: | Objective: Heat shock proteins act as chaperones at the molecular level and therefore they have been investigated in numerous diseases associated with oxidative stress, including obesity. The aim of this study was to investigate the possible associations of genetic variability in the 3´-untranslated region of the HSPB7 gene (rs1048261) with anthropometric and dietary parameters in a cohort of lean and obese Central European subjects. Methods: A total of 708 Central European Caucasian individuals were enrolled in this study, 415 obese subjects and 293 non-obese subjects. The rs1048261 genotypes were established using a conventional PCR-based methodology. Results: Significant differences were observed in the total daily fat intake between subjects with AT and TT genotypes (82.6 ± 29.2 g vs. 74.1 ± 31.3 g, p = 0.023) and also borderline significance in daily proportion of fat in the diet between AA and TT genotypes (36.0 ± 4.4% vs. 33.3 ± 5.9%, p = 0.061). Based on the linear regression model we found association between rs1048261 genotype and body fat percentage. Conclusions: To the best of our knowledge, this is the first study which reports an association of defined genetic variability in the HSPB7 gene, rs1048261, with obesity and its associated anthropometric characteristics and dietary composition. |
| Databáze: | OpenAIRE |
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