Interleukin-3-like activity levels in pregnant women: possible modulation by progesterone
| Autor: | Meir Djaldetti, D. Sredni, Yehuda Shoenfeld, R. Zigelman, P. Fishman, Y. Shamir, J. Hart, O. Inbar, D. Feldberg |
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| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Immunology Peripheral blood mononuclear cell Pregnancy Internal medicine Immunology and Allergy Medicine Humans Progesterone Interleukin 3 business.industry Obstetrics and Gynecology Interleukin medicine.disease Fetal Blood Cytokine Endocrinology Reproductive Medicine Cord blood Leukocytes Mononuclear Gestation Female Interleukin-3 business Hormone |
| Zdroj: | Journal of reproductive immunology. 22(2) |
| ISSN: | 0165-0378 |
| Popis: | Human interleukin-3-like activity (IL-3-LA), a factor possessing similar characteristics to interleukin-3 and having clony stimulating factor (CSF) activity, has recently been defined. In the present study, IL-3-LA levels in the sera of women before and after delivery were examined. The results indicate a significant increase in IL-3-LA levels in women before delivery as compared to IL-3-LA levels after delivery or to non-pregnant healthy women. The ability of mononuclear cells from women before and after delivery to produce IL-3-LA was similar to that of mononuclear cells from cord blood. In addition, the effect of progesterone on in vitro IL-3-LA production was examined and a stimulatory dose-dependent effect was observed. These observations point to the hypothesis that during pregnancy IL-3-LA levels are modulated by progesterone. With placental loss, the IL-3-LA in the sera decreases, although the mononuclear cells previously affected by the hormone continue to produce cytokines. |
| Databáze: | OpenAIRE |
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