Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats
| Autor: | Brian E. Carlson, Steven E. Whitesall, Feng Gu, Daniel E. Michele, E. Benjamin Randall, Daniel A. Beard, Gregory D. Fink, Kimber Converso-Baran |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Baroreceptor Cardiology Blood Pressure Pressoreceptors Baroreflex Rats Inbred WKY Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Spontaneously hypertensive rat Heart Rate Internal medicine Rats Inbred SHR Heart rate Genetic model Medicine Animals cardiovascular diseases Sodium Chloride Dietary Denervation Rats Inbred Dahl business.industry musculoskeletal neural and ocular physiology General Medicine Complex traits Pathophysiology Rats 030104 developmental biology Blood pressure 030220 oncology & carcinogenesis Hypertension cardiovascular system Female business circulatory and respiratory physiology Research Article |
| Zdroj: | JCI Insight JCI Insight, Vol 5, Iss 19 (2020) |
| ISSN: | 2379-3708 |
| Popis: | The spontaneously hypertensive rat (SHR) is a genetic model of primary hypertension with an etiology that includes sympathetic overdrive. To elucidate the neurogenic mechanisms underlying the pathophysiology of this model, we analyzed the dynamic baroreflex response to spontaneous fluctuations in arterial pressure in conscious SHRs, as well as in the Wistar-Kyoto (WKY), the Dahl salt-sensitive, the Dahl salt-resistant, and the Sprague-Dawley rat. Observations revealed the existence of long intermittent periods (lasting up to several minutes) of engagement and disengagement of baroreflex control of heart rate. Analysis of these intermittent periods revealed a predictive relationship between increased mean arterial pressure and progressive baroreflex disengagement that was present in the SHR and WKY strains but absent in others. This relationship yielded the hypothesis that a lower proportion of engagement versus disengagement of the baroreflex in SHR compared with WKY contributes to the hypertension (or increased blood pressure) in SHR compared with WKY. Results of experiments using sinoaortic baroreceptor denervation were consistent with the hypothesis that dysfunction of the baroreflex contributes to the etiology of hypertension in the SHR. Thus, this study provides experimental evidence for the roles of the baroreflex in long-term arterial pressure regulation and in the etiology of primary hypertension in this animal model. Baroreflex dysfunction contributes to the etiology of hypertension in a genetic model of primary hypertension. |
| Databáze: | OpenAIRE |
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