Sexual Dimorphism of Metabolomic Profile in Arterial Hypertension
| Autor: | Boubacar Sidiki Ibrahim Dramé, Mahamadou Diakite, Klétigui Casimir Dembélé, Yaya Goïta, Gilles Simard, MB Diarra, Yaya Kassogue, Juan Manuel Chao de la Barca, Asmaou keita, Bakary Mamadou Cissé, Floris Chabrun, Delphine Mirebeau-Prunier, Pascal Reynier |
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| Přispěvatelé: | Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université des sciences, des techniques et des technologies de Bamako (USTTB), Centre Hospitalier Universitaire [Bamako, Mali] (CHU Bamako), Département de Biochimie et Génétique [Angers], Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), This work was supported by the programme de Formation des Formateurs (PFF) de l’Université des Sciences Juridiques et Politique de Bamako (l’USJPB), the Projet d’Appui au Développement de l’Enseignement Supérieur (PADES), the Institut National de la Santé et de la Recherche Médicale (INSERM), the Centre National de la Recherche Scientifique (CNRS), the University of Angers, and the University Hospital of Angers., Université des Sciences, des Techniques et des Technologies de Bamako (USTTB), MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Bodescot, Myriam |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Ornithine Arginine Symmetric dimethylarginine [SDV]Life Sciences [q-bio] Physiology lcsh:Medicine 030204 cardiovascular system & hematology Predictive markers Article 03 medical and health sciences 0302 clinical medicine Insulin resistance Metabolomics Sex Factors [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Healthy control medicine Humans Least-Squares Analysis lcsh:Science ComputingMilieux_MISCELLANEOUS Principal Component Analysis Multidisciplinary business.industry lcsh:R Discriminant Analysis Middle Aged medicine.disease 3. Good health [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system Sphingomyelins Sexual dimorphism 030104 developmental biology Hypertension Metabolome Phosphatidylcholines lcsh:Q Female business Biomarkers Targeted metabolomics |
| Zdroj: | Scientific Reports Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-64329-1⟩ Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.7517. ⟨10.1038/s41598-020-64329-1⟩ Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) Scientific Reports, 2020, 10 (1), pp.7517. ⟨10.1038/s41598-020-64329-1⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-64329-1⟩ |
| Popis: | Metabolomic studies have demonstrated the existence of biological signatures in blood of patients with arterial hypertension, but no study has hitherto reported the sexual dimorphism of these signatures. We compared the plasma metabolomic profiles of 28 individuals (13 women and 15 men) with essential arterial hypertension with those of a healthy control group (18 women and 18 men), using targeted metabolomics. Among the 188 metabolites explored, 152 were accurately measured. Supervised OPLS-DA (orthogonal partial least squares-discriminant analysis) showed good predictive performance for hypertension in both sexes (Q2cum = 0.59 in women and 0.60 in men) with low risk of overfitting (p-value-CV ANOVA = 0.004 in women and men). Seventy-five and 65 discriminant metabolites with a VIP (variable importance for the projection) greater than 1 were evidenced in women and men, respectively. Both sexes showed a considerable increase in phosphatidylcholines, a decrease in C16:0 with an increase in C28:1 lysophosphatidylcholines, an increase in sphingomyelins, as well as an increase of symmetric dimethylarginine (SDMA), acetyl-ornithine and hydroxyproline. Twenty-nine metabolites, involved in phospholipidic and cardiac remodeling, arginine/nitric oxide pathway and antihypertensive and insulin resistance mechanisms, discriminated the metabolic sexual dimorphism of hypertension. Our results highlight the importance of sexual dimorphism in arterial hypertension. |
| Databáze: | OpenAIRE |
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