Squamous cell carcinoma of unknown primary origin in a dog presenting with bone metastasis
| Autor: | Julio Edward Hough Monteiro, Rosemeri de Oliveira Vasconcelos, Felipe Ruiz Sueiro, Mirela Tinucci-Costa, Sabryna Gouveia Calazans, Paulo César Jark, Oscar Rodrigo Sierra Matiz, Andresa Matsui, Rafaela Bortolotti Viéra, Denner Santos dos Anjos |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms 040301 veterinary sciences medicine.medical_treatment canine Vimentin Bone Neoplasms Amputation Surgical 0403 veterinary science 03 medical and health sciences Dogs metastatic cancer Scapula Drug Therapy carcinoma of unknown primary medicine Carcinoma Biomarkers Tumor Internal Medicine Neoplasm Animals 030304 developmental biology 0303 health sciences Chemotherapy General Veterinary biology business.industry Bone metastasis 04 agricultural and veterinary sciences medicine.disease Note Immunohistochemistry Kidney Neoplasms Amputation biology.protein Carcinoma Squamous Cell Keratins Neoplasms Unknown Primary Female business neoplasm |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 |
| Popis: | A 10-year-old female American Pit Bull dog was diagnosed with metastatic undifferentiated carcinoma of the scapula. Immunohistochemistry showed positive immunoexpression for cytokeratins (AE1/AE3, 34BE12, CK7) and vimentin, confirming squamous cell carcinoma. No evidence of nodules was found in the complete physical examination and imaging procedures conducted. The patient was diagnosed with carcinoma of unknown primary origin. Amputation and adjuvant chemotherapy with doxorubicin and piroxicam were performed, but the patient died of respiratory failure after 737 days of diagnosis. Necropsy confirmed undifferentiated carcinoma infiltrating the lungs and kidneys, and showing the same immunoexpression as the tumor in the scapula. Amputation associated with chemotherapy extended the overall survival time of this patient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|