Changes in Factors V and VIII after Administration of Adrenaline to Normal and Splenectomized Rats
| Autor: | P. Pudlaak, I. Farská, E. Deimlová |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
medicine.medical_specialty
Factor VIII Epinephrine biology business.industry medicine.medical_treatment Factor V Hematology Unilateral nephrectomy Body weight Nephrectomy Rats Endocrinology Internal medicine Splenectomy medicine biology.protein Animals Blood Coagulation Tests business Blood coagulation test |
| Zdroj: | British Journal of Haematology. 16:373-380 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1969.tb00414.x |
| Popis: | Summary: Changes in Factors V and VIII were studied in normal, unilaterally nephrectomized, and splenectomized rats. Adrenaline in a dose of 3 or 6 μg. per 200 g. body weight subcutaneously induced a significant but not very large increase in the activity of Factors V and VIII. A similar increase occurred in splenectomized and unilaterally nephrectomized rats. However, after unilateral nephrectomy an injection of adrenaline did not further raise the concentration of Factor VIII; and in Splenectomized rats a decrease in Factor VIII was found after adrenaline. The level of Factor V was not further significantly altered in either operated group after giving adrenaline. The mechanism of these changes is discussed but remains to be elucidated. |
| Databáze: | OpenAIRE |
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