Renal aquaporins and water balance disorders
| Autor: | Robert A. Fenton, Cecilia Hvitfeldt Fuglsang, Hanne B. Moeller |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
DOWN-REGULATION Vasopressin vasopressin Endocrinology Diabetes and Metabolism 030232 urology & nephrology URINARY CONCENTRATING ABILITY Aquaporin Biology Aquaporins COLLECTING DUCT CELLS CHANNEL EXPRESSION INNER MEDULLA NDI 03 medical and health sciences water balance 0302 clinical medicine Endocrinology nephrogenic diabetes insipidus medicine Animals Humans NITRIC-OXIDE SYNTHASE water retention Kidney Water-Electrolyte Balance CHRONIC HEART-FAILURE aquaporin VASOPRESSIN TYPE-2 RECEPTOR 030104 developmental biology medicine.anatomical_structure NEPHROGENIC DIABETES-INSIPIDUS Biochemistry concentrating mechanism Treatment strategy Kidney Diseases LITHIUM-INDUCED NDI thiazide Water balance disorders Homeostasis Function (biology) |
| Zdroj: | Moeller, H B, Fuglsang, C H & Fenton, R A 2016, ' Renal aquaporins and water balance disorders ', Best Practice & Research: Clinical Endocrinology & Metabolism, vol. 30, no. 2, pp. 277-288 . https://doi.org/10.1016/j.beem.2016.02.012 |
| ISSN: | 1521-690X |
| DOI: | 10.1016/j.beem.2016.02.012 |
| Popis: | Aquaporins (AQPs) are a 13 member family (AQP0-12) of proteins that act as channels, through which water and, for some family members, glycerol, urea and other small solutes can be transported. Aquaporins are highly abundant in kidney epithelial cells where they play a critical role with respect to water balance. In this review we summarize the current knowledge with respect to the localization and function of AQPs within the kidney tubule, and their role in mammalian water homeostasis and the water balance disorders. Overviews of practical aspects with regard to differential diagnosis for some of these disorders, alongside treatment strategies are also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect