Improvement in quality of oocytes in polycystic ovarian syndrome in programs of in vitro fertilization

Autor:	N. L. Petuhova, K. A. Tsaturova, A. V. Markin, A. S. Mikhaylyukova, V. A. Levin, E. V. Vartanyan, E. A. Devyatova, E. M. Steptsova
Rok vydání:	2017
Předmět:	Adult Infertility medicine.medical_specialty Pregnancy Rate endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Fertilization in Vitro Preconception Care Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Pregnancy Humans Medicine Inositol In patient Sperm Injections Intracytoplasmic 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Obstetrics Ovary Uterus Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Treatment Outcome chemistry Oocytes Female business Infertility Female Polycystic Ovary Syndrome
Zdroj:	Gynecological Endocrinology. 33:8-11
ISSN:	1473-0766 0951-3590
DOI:	10.1080/09513590.2017.1399699
Popis:	Inositol therapy is aimed at improving the quality of oocytes during preconception care in patients with polycystic ovarian syndrome (PCOS), a cause of infertility and reproductive dysfunction. The objectives of this observational comparative multicentre study were to evaluate the effectiveness of inositol in improving the quality of oocytes/embryos and IVF cycle outcome. Group 1 patients (N = 133) received inositol 1000 mg (Inofert or Nutrilinea) + folic acid 0.1 mg. Group 2 consisted of patients with preserved ovarian reserve without PCOS (N = 137), not administered inositol prior to pregnancy. Effectiveness criteria were numbers of mature oocytes and good quality embryos, pregnancy rates per ET, 'take home baby' index and miscarriage rates. Pregnancy rates per ET (87.0% vs. 87.4%), 'take home baby' index (79.6% vs. 89.4%) and miscarriage rates (14.3% vs. 10.6%) were comparable. Use of inositol in patients with PCOS during preconception care is an effective method allowing improvement of oocytes quality and positively affecting IVF cycle prognosis. High pregnancy rates per ET and 'take home baby' index after treatment are justifying inositol usage in patients with PCOS and infertility.
Databáze:	OpenAIRE
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