Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids
| Autor: | Rudolf Konrad Allemann, Melodi Demiray, David James Miller |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
amorphadiene synthase
sesquiterpenoids 010402 general chemistry 01 natural sciences Full Research Paper substrate engineering lcsh:QD241-441 Terpene lcsh:Organic chemistry medicine Organic chemistry Artemisinin lcsh:Science chemistry.chemical_classification 010405 organic chemistry Amorphadiene Organic Chemistry 3. Good health 0104 chemical sciences Chemistry Enzyme chemistry artemisinin oxygenated terpenoids Sesquiterpene cyclase lcsh:Q terpenes medicine.drug |
| Zdroj: | Beilstein Journal of Organic Chemistry Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2184-2190 (2019) |
| ISSN: | 1860-5397 |
| Popis: | 8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly controlled carbocationic chemistry of this sesquiterpene cyclase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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