MR imaging of acute intermittent porphyria mimicking reversible posterior leukoencephalopathy syndrome
| Autor: | B Kinkel, N Utz, H Bewermeyer, J P Hedde |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Abdominal pain Brain Edema Fluid-attenuated inversion recovery Nitric Oxide Diagnosis Differential White matter Neuroimaging Seizures medicine Humans Radiology Nuclear Medicine and imaging Acute intermittent porphyria Neuroradiology medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Syndrome medicine.disease Magnetic Resonance Imaging Porphyria medicine.anatomical_structure Porphyria Acute Intermittent Hypertension Female Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Neuroradiology. 43:1059-1062 |
| ISSN: | 1432-1920 0028-3940 |
| DOI: | 10.1007/s002340100616 |
| Popis: | Reversible posterior leukoencephalopathy syndrome (PLS) is characterized by headache, altered mental function, visual disturbances and seizures. Neuroimaging studies suggest a white-matter oedema, predominantly in the posterior parietal-temporal-occipital regions of the brain. We present the case of a 30-year-old woman who had suffered her first attack of acute intermittent porphyria (AIP). Following 1 week of abdominal pain she developed several generalized seizures, and hallucinations, and exhibited a progressive deterioration of the consciousness. T2-weighted images, especially fluid-attenuated inversion recovery (FLAIR) sequences showed bilateral lesions in the posterior frontal, parietal and occipital cortex and subcortical white matter. Following treatment with haematin and a high carbohydrate diet the patient's condition improved. Follow-up magnetic resonance imaging (MRI) revealed complete resolution of the lesions. To our knowledge, this is the first report concerning a completely reversible PLS in AIP. |
| Databáze: | OpenAIRE |
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