Evaluation of the Impact of a New Synthetic Vitamin E-Bonded Membrane on the Hypo-Responsiveness to the Erythropoietin Therapy in Hemodialysis Patients: A Multicenter Study
| Autor: | Marco Peruzzini, Sauro Urbini, Franca Giacchino, Marta Piroddi, Francesco Locatelli, Laura Fattori, Lucia Del Vecchio, Francesco Galli, Roberto Broccoli, Simeone Andrulli, Sara Viganò, Massimo Concetti, Maria Cossu, Paolo Conti, Daniela Angelini, Filippo Aucella, Giorgio Punzo, Salvatore Di Giulio |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Anemia medicine.medical_treatment 030232 urology & nephrology Renal function Aged Erythropoietin Female Follow-Up Studies Humans Kidney Function Tests Middle Aged Treatment Outcome Membranes Artificial Renal Dialysis Vitamin E 030204 cardiovascular system & hematology medicine.disease_cause Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Medicine Membranes business.industry Hematology General Medicine medicine.disease Clinical trial Endocrinology Nephrology Artificial Hemodialysis business Oxidative stress medicine.drug |
| Zdroj: | Blood purification. 43(4) |
| ISSN: | 1421-9735 |
| Popis: | Background: Oxidative stress has been related to hypo-response to erythropoiesis-stimulating agents (ESAs) in hemodialysis (HD) patients. The aim of this study was to verify whether vitamin E (ViE) on a synthetic polysulfone dialyzer can improve ESA responsiveness. Methods: This controlled, multicenter study involved 93 HD patients on stable ESA therapy, who were randomized to either ViE-coated polysulfone dialyzer or to a low-flux synthetic dialyzer. The primary outcome measure was the change in ESA resistance index (ERI) from baseline. Results: Mean ERI decreased in the ViE group by 1.45 IU/kg*g/dl and increased in the control group by 0.53 IU/kg*g/dl, with a mean difference of 1.98 IU/kg*g/dl (p = 0.001 after adjusting for baseline ERI, as foreseen by the study protocol). Baseline ERI was inversely related to its changes during follow-up only in the control group (R2 = 0.29). Conclusions: The ViE dialyzer can improve ESA response in HD patients. Changes in ERI during follow-up are independent from baseline ERI only in the ViE group. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=453442. |
| Databáze: | OpenAIRE |
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