Sublingual administration of Δ9-tetrahydrocannabinol/β-cyclodextrin complex increases the bioavailability of Δ9-tetrahydrocannabinol in rabbits
| Autor: | Jussi Tervonen, Tomi Järvinen, Kristiina Järvinen, Janne Mannila, Pekka Jarho |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Administration Sublingual Administration Oral Biological Availability Pharmacology General Biochemistry Genetics and Molecular Biology Sublingual administration Excipients Oral administration mental disorders medicine Animals Dronabinol General Pharmacology Toxicology and Pharmaceutics Tetrahydrocannabinol Beta (finance) Chromatography High Pressure Liquid Absolute bioavailability chemistry.chemical_classification Cyclodextrin Chemistry Drug Administration Routes organic chemicals beta-Cyclodextrins General Medicine Bioavailability Injections Intravenous Female Rabbits medicine.drug |
| Zdroj: | Life Sciences. 78:1911-1914 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2005.08.025 |
| Popis: | The bioavailability of Delta(9)-tetrahydrocannabinol (THC) was determined after its sublingual administration as solid THC/beta-cyclodextrin (THC/beta-CD) complex, and was compared to oral administration of ethanolic THC, in rabbits. The absolute bioavailability of THC after sublingual administration of solid THC/beta-CD complex powder (16.0 +/- 7.5%; mean +/- SD; n = 4) is higher than the bioavailability of THC after oral administration of ethanolic THC solution (1.3 +/- 1.4%; mean +/- SD; n = 4). The results suggest that sublingual administration of THC/beta-CD complex is a useful tool in improving absolute bioavailability of THC. |
| Databáze: | OpenAIRE |
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