Sucralose and Cardiometabolic Health: Current Understanding from Receptors to Clinical Investigations
| Autor: | Guillaume Walther, Matthieu Roustit, Sylvain Battault, Grégory Meyer, Alonso Romo-Romo, Loïc Briand, S. Risdon, Paloma Almeda-Valdes |
|---|---|
| Přispěvatelé: | Avignon Université (AU), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], HP2, Pole Biol CHU Grenoble (INSERM, U1042), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Agence National de la Recherche (ANR) + Fondation Francophone pour la Recherche sur le Diabete + Abbott, AstraZeneca, Eli Lilly, Merck Sharp & Dohme + Novo Nordisk, Avignon Universite + Conseil Regional Provence-Alpes-Cote d'Azur., American Society for Nutrition members (ASN), ANR-19-CE21-0003,SOSweet,Effets des édulcorants sur la fonction vasculaire : identification du rôle de la famille des récepteurs du goût sucré T1R(2019) |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Non-Nutritive Sweeteners Sucrose Sucralose Calorie glucose metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism Review Overweight Gut flora Added sugar 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Environmental health medicine Humans Glucose homeostasis 2. Zero hunger Nutrition and Dietetics biology business.industry sweet and bitter taste receptor Type 2 Diabetes Mellitus sucralose taste signaling cascade cardiovascular health biology.organism_classification 3. Good health 030104 developmental biology Diabetes Mellitus Type 2 chemistry Cardiovascular Diseases low-calorie sweetener medicine.symptom business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Weight gain Food Science |
| Zdroj: | Adv Nutr Advances in Nutrition Advances in Nutrition, Oxford University Press, 2021, 12 (4), pp.1500-1513. ⟨10.1093/advances/nmaa185⟩ |
| ISSN: | 2161-8313 2156-5376 |
| DOI: | 10.1093/advances/nmaa185 |
| Popis: | International audience; The excess consumption of added sugar is consistently found to be associated with weight gain, and a higher risk of type 2 diabetes mellitus, coronary heart disease, and stroke. In an effort to reduce the risk of cardiometabolic disease, sugar is frequently replaced by low- and null-calorie sweeteners (LCSs). Alarmingly, though, emerging evidence indicates that the consumption of LCSs is associated with an increase in cardiovascular mortality risk that is amplified in those who are overweight or obese. Sucralose, a null-caloric high-intensity sweetener, is the most commonly used LCS worldwide, which is regularly consumed by healthy individuals and patients with metabolic disease. To explore a potential causal role for sucralose in increased cardiovascular risk, this present review summarizes the preclinical and clinical data from current research detailing the effects of sucralose on systems controlling food intake, glucose homeostasis, and gut microbiota. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|