Synthesis, spectroscopic and antimicrobial studies of La(III), Ce(III), Sm(III) and Y(III) Metformin HCl chelates
| Autor: | Fathi M. Al-Azab, Yasmin M.S. Jamil, Mohamed I. Kobeasy, Hussein M.A. Al-Maydama, Ragab R. Amin, Moamen S. Refat |
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| Rok vydání: | 2014 |
| Předmět: |
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Molecular Spectrophotometry Infrared Metal ions in aqueous solution Inorganic chemistry Electrolyte Microbial Sensitivity Tests Lanthanoid Series Elements Analytical Chemistry Metal chemistry.chemical_compound Anti-Infective Agents Coordination Complexes Humans Chelation Instrumentation Spectroscopy Chelating Agents Bacteria Fungi Bacterial Infections Atomic and Molecular Physics and Optics Metformin Spectrometry Fluorescence chemistry Mycoses Elemental analysis visual_art visual_art.visual_art_medium Melting point Dimethylformamide Thermodynamics Spectrophotometry Ultraviolet Methanol Nuclear chemistry |
| Zdroj: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 142 |
| ISSN: | 1873-3557 |
| Popis: | Metal complexes of Metformin hydrochloride were prepared using La(III), Ce(III), Sm(III) and Y(III). The resulting complexes were discussed and synthesized to serve as potential insulin-mimetic. Some physical properties and analytical data of the four complexes were checked. The elemental analysis shows that La(III), Ce(III) Sm(III) and Y(III) formed complexes with Metformin in 1:3 (metal:MF) molar ratio. All the synthesized complexes are white and possess high melting points. These complexes are soluble in dimethylsulfoxide and dimethylformamide, partially soluble in hot methanol and insoluble in water and some other organic solvents. From the spectroscopic (infrared, UV-vis and florescence), effective magnetic moment and elemental analyses data, the formula structures are suggested. The results obtained suggested that Metformin reacted with metal ions as a bidentate ligand through its two imino groups. The molar conductance measurements proved that the Metformin complexes are slightly electrolytic in nature. The kinetic thermodynamic parameters such as: E(∗), ΔH(∗), ΔS(∗) and ΔG(∗) were estimated from the DTG curves. The antibacterial evaluations of the Metformin and their complexes were also performed against some gram positive, negative bacteria as well as fungi. |
| Databáze: | OpenAIRE |
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