Predonation Single Kidney Glomerular Filtration Rate in Living Kidney Transplantation to Predict Graft Function and Donor Functional Gain
| Autor: | Bénédicte Janbon, Rachel Tetaz, Nicolas Terrier, Stéphane Charara, Thomas Jouve, Paolo Malvezzi, Johan Noble, Hamza Naciri Bennani, Matthieu Roustit, Diane Giovannini, Jean-Jacques Rambeaud, Gaelle Fiard, Isabelle Gomez, Morgane Heitz, Lionel Rostaing |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Renal function Transplants Kidney Graft function Single kidney Living Donors Medicine Humans Transplantation Homologous Prospective Studies Retrospective Studies Transplantation business.industry Living kidney transplantation Middle Aged University hospital Kidney Transplantation medicine.anatomical_structure Treatment Outcome Dimercaptosuccinic acid Surgery Female business Statistical correlation medicine.drug Glomerular Filtration Rate |
| Zdroj: | Transplantation proceedings. 52(3) |
| ISSN: | 1873-2623 |
| Popis: | Background The 2 main objectives regarding living kidney transplant are to provide optimal graft function and to ensure the safety of donation. Our study hypothesized that the glomerular filtration rate of a single kidney (skGFR), when transplanted, might predict graft function and that the skGFR of the remaining kidney could predict donor functional gain. Methods A prospective monocentric study was conducted at Grenoble-Alpes University Hospital. Twenty couples of donors and recipients were included. Dimercaptosuccinic acid renal scintigraphy and 51Cr-ethylene-diamine tetra-acetic acid clearance were evaluated predonation to calculate skGFR. All patients had renal function according to 51Cr-ethylene-diamine tetra-acetic acid clearance at 1 year post transplant to assess graft function and donor functional gain. All donors had normal renal function predonation. Results At 1 year post transplant, median glomerular filtration rate of the graft was 50 mL/min/1.73 m2 (range, 46-56 mL/min/1.73 m2) and donor median glomerular filtration rate was 59 mL/min/1.73 m2 (range, 55-74 mL/min/1.73 m2). Median functional gain was 20 mL/min/1.73 m2 (range, 12-22 mL/min/1.73 m2). No statistical correlation was found between skGFR of the transplanted kidney and graft function at 1 year (R2 = 0.096, P = .7). For the donor, functional gain was not associated with predonation skGFR of the remaining kidney (R2 = 0.17, P = .5). A statistical difference was found between donor functional gain (18 [SD, 10] mL/min) and recipient gain (delta between skGFR before and after transplant, 7 [SD, 16] mL/min; P = .02). Conclusion Predonation skGFR of the transplanted kidney had no influence on renal allograft function at 1 year post transplant. Similarly, there was no association between measured skGFR of the remaining kidney and donor functional gain at 1 year. |
| Databáze: | OpenAIRE |
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