Growth patterns of uninfected children born to women living with perinatally versus nonperinatally acquired HIV
| Autor: | Denise L. Jacobson, Deborah Kacanek, Wendy Yu, Paige L. Williams, Kunjal Patel, Jennifer Jao, Mitchell E. Geffner, Linda A. DiMeglio, Russell B. Van Dyke |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Immunology Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Article Young Adult Pregnancy medicine Humans Immunology and Allergy Prospective Studies Early childhood Pregnancy Complications Infectious Young adult Child Prospective cohort study Triceps Skinfold Thickness Singleton business.industry Infant Newborn Parturition Infant Anthropometry Infectious Disease Transmission Vertical Infectious Diseases Child Preschool Female business Differential growth Demography |
| Zdroj: | AIDS |
| ISSN: | 1473-5571 0269-9370 |
| Popis: | The aim of this study was to compare long-term growth between HIV-exposed uninfected children (CHEU) born to women with perinatally acquired HIV (CHEU-PHIV) and CHEU born to women with nonperinatally acquired HIV (CHEU-NPHIV).A longitudinal analysis of anthropometric measurements from a U.S.-based multisite prospective cohort study enrolling CHEU and their mothers since April 2007.CHEU were evaluated for growth annually from birth through age 5 and again at age 7 years. Z-scores were calculated using U.S. growth references for weight (WTZ), height (HTZ), and weight-for-length or BMI-for-age (WLZ/BMIZ). Mid-upper arm circumference (MUACZ) and triceps skinfold thickness (TSFZ) Z-scores were obtained from ages 1 and 2, respectively, through age 7 years. Piecewise mixed-effects models, overall and stratified by race and sex, were fit to assess differential growth patterns across age by maternal PHIV status.One thousand four hundred fifty-four singleton infants (286 CHEU-PHIV and 1168 CHEU-NPHIV) were included. CHEU-PHIV had slower growth rates than CHEU-NPHIV for WTZ and WLZ/BMIZ at earlier ages and continued to have lower mean WTZ [-0.27, 95% confidence interval (95% CI): -0.50, -0.04] and WLZ/BMIZ (-0.39, 95% CI: -0.67, -0.11) through age 7. Among non-Black boys, CHEU-PHIV had slightly lower WTZ and WLZ/BMIZ at birth than CHEU-NPHIV and these growth deficits persisted through age 7 years.Compared with CHEU-NPHIV, CHEU-PHIV had diminished growth in early childhood with differences most pronounced among non-Black male children. Further longitudinal follow-up of CHEU-PHIV into young adulthood is needed to understand whether these early effects of maternal PHIV status on growth persist and have other health consequences. |
| Databáze: | OpenAIRE |
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