Anti-SARS-CoV-2 S-RBD IgG Antibody Responses after COVID-19 mRNA Vaccine in the Chronic Disorder of Consciousness: A Pilot Study

Autor: Maria Elena Pugliese, Riccardo Battaglia, Antonio Cerasa, Maria Girolama Raso, Francesco Coschignano, Angela Pagliuso, Roberta Bruschetta, Giovanni Pugliese, Paolo Scola, Paolo Tonin
Rok vydání: 2021
Předmět:
Zdroj: Journal of Clinical Medicine, Vol 10, Iss 5830, p 5830 (2021)
Journal of clinical medicine (2021). doi:10.3390/jcm10245830
info:cnr-pdr/source/autori:Maria Elena Pugliese; Riccardo Battaglia; Antonio Cerasa; Maria Girolama Raso; Francesco Coschignano; Angela Pagliuso; Roberta Bruschetta; Giovanni Pugliese; Paolo Scola; Paolo Tonin/titolo:Anti-SARS-CoV-2 S-RBD IgG Antibody Responses after COVID-19 mRNA Vaccine in the Chronic Disorder of Consciousness: A Pilot Study/doi:10.3390%2Fjcm10245830/rivista:Journal of clinical medicine/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume
Journal of Clinical Medicine
Journal of Clinical Medicine; Volume 10; Issue 24; Pages: 5830
ISSN: 2077-0383
DOI: 10.3390/jcm10245830
Popis: Objective: In the last year, a large amount of research has investigated the anti-spike protein receptor-binding domain (S-RBD) antibody responses in patients at high risk of developing severe acute respiratory syndrome because of COVID-19 infection. However, no data are available on the chronic disorder of consciousness (DOC). Methods: Here, we evaluated anti-S-RBD IgG levels after vaccination in chronic DOC patients compared with demographically matched healthy controls (HC) by indirect chemiluminescence immunoassay. All individuals completed a two-dose-cycle vaccination with Pfizer mRNA vaccine (BNT162b2), and antibody responses were evaluated at 30 and 180 days after the administration of the second dose of vaccination. Results: We compared 32 DOC patients with 34 demographically matched healthy controls. Both DOC and HC groups showed a similar antibody response at 30 days, whereas at follow-up (180 days) DOC patients were characterized by lower S-RBD IgG levels with respect to controls. Additional multiple regression analyses including demographical and clinical comorbidities as predictors revealed that age was the only factor associated with the decrease in S-RBD IgG levels at follow-up (180 days). Elderly individuals of both groups were characterized by a reduction in the antibody responses with respect to younger individuals. Conclusions: Our results show an efficacy seroconversion in DOC patients in the first period after vaccination, which significantly declines over time with respect to healthy controls.
Databáze: OpenAIRE
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