Oligoclonal bands in acute schizophrenia: a negative search
| Autor: | N. M. Papadopoulos, J. R. Stevens, M. Resnick |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Immunofixation Psychosis Oligoclonal band Acute schizophrenia Immunoglobulins Immunoglobulin E Cerebrospinal fluid HIV Seropositivity mental disorders medicine Humans Schizophrenia Paranoid biology business.industry Oligoclonal Bands medicine.disease Psychiatry and Mental health Schizophrenia Immunoglobulin G Acute Disease Immunology biology.protein Female Schizophrenic Psychology Antibody business |
| Zdroj: | Acta Psychiatrica Scandinavica. 81:262-264 |
| ISSN: | 1600-0447 0001-690X |
| DOI: | 10.1111/j.1600-0447.1990.tb06493.x |
| Popis: | Numerous immunologic abnormalities have been reported in patients with schizophrenia, suggesting that this disorder may in some cases represent a viral or immunologic disorder of the brain. To further examine this question, evidence for intrathecal production of immunoglobulin (IgG) and immunoglobulin oligoclonal bands (OCB) was sought in patients with acute or early schizophrenia. Using high resolution zone electrophoresis and immunofixation, there was no evidence for intrathecal IgG generation in 5 of 5 patients tested. One of 9 patients had OCBs in CSF. This man, although he had a typical history of schizophrenia, tested positive for human immunodeficiency virus antibody in serum. |
| Databáze: | OpenAIRE |
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