Aminophosphonates and aminophosphonic acids with tetrasubstituted stereogenic center: diastereoselective synthesis from cyclic ketimines
| Autor: | Marek Daszkiewicz, Anna Brol, Jakub Iwanejko, Tomasz K. Olszewski, Bartłomiej M. Szyja, Elżbieta Wojaczyńska |
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| Rok vydání: | 2019 |
| Předmět: |
Tris
Reaction conditions Trimethylsilyl 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Asymmetric induction 0104 chemical sciences Stereocenter chemistry.chemical_compound Nucleophile Physical and Theoretical Chemistry |
| Zdroj: | Organicbiomolecular chemistry. 17(31) |
| ISSN: | 1477-0539 |
| Popis: | New chiral tetrasubstituted aminophosphonic acid derivatives of hexahydroquinoxalin-2(1H)-one were synthesised via highly diastereoselective hydrophosphonylation of the corresponding imines with tris(trimethylsilyl) phosphite as phosphorus nucleophile. High asymmetric induction, good yields, mild reaction conditions, and ease of purification of the final products are the key advantages of the presented protocol. |
| Databáze: | OpenAIRE |
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