Zinc-Mediated Formation of Trifluoromethyl Ethers from Alcohols and Hypervalent Iodine Trifluoromethylation Reagents
| Autor: | Katrin Niedermann, Antonio Togni, Daniel Stolz, Raphael Aardoom, Raffael Koller, Kyrill Stanek |
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| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Trifluoromethyl Trifluoromethylation Cyclohexanones Hypervalent molecule Molecular Conformation chemistry.chemical_element General Chemistry Zinc Fluorine General Medicine Iodine Crystallography X-Ray Catalysis chemistry.chemical_compound chemistry Aliphatic alcohol Reagent Alcohols Organic chemistry Alkyl Ethers |
| Zdroj: | Angewandte Chemie. 121:4396-4400 |
| ISSN: | 1521-3757 0044-8249 |
| DOI: | 10.1002/ange.200900974 |
| Popis: | A (fluor)ry of activity: The transfer of an intact trifluoromethyl group from a hypervalent iodine reagent to an aliphatic alcohol occurs smoothly upon activation by zinc bis(triflimide). This constitutes a straightforward method for the preparation of trifluoromethoxy alkyl derivatives, compounds otherwise difficult to access. |
| Databáze: | OpenAIRE |
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